King’s College London, Department of Twin Research, UK
The Department of Twin Research and Genetic Epidemiology (DTR) is part of the Division of Genetics and Molecular Medicine at King’s College London. It encompasses the biggest adult twin registry in the UK with over 11,000 twins and possesses an international track record in the genetic and environmental aetiology of age-related complex traits and diseases. The cohort is one of the most highly phenotyped in the world, with extensive cross sectional and longitudinal biological and questionnaire data gathered over the course of >20 years.
The current focus of research is exploring the integration of multiple omics tools to more precisely define phenotypes and understand disease processes. This includes epigenomics, metabolomics nutriomics, genomics, glycomics, expression-omics, and microbiome data.
The DTR is strongly committed to sharing this large collection of data with the international scientific community to promote and enable further scientific research and generate new ideas and knowledge. To date it has enabled multiple collaborations with over 100 groups worldwide and lead to the publication of over 700 research papers.
King’s College London, Institute of Psychiatry, UK
The Institute of Psychiatry, Psychology & Neuroscience (IoPPN) –a School of King’s College London – is Europe’s largest centre for research and postgraduate education in psychiatry, psychology, basic and clinical neuroscience. World-renowned for the quality of its research and, for psychiatry and psychology, it is the most cited research centre outside the US and the second most cited research centre in the world – as ranked by Thomson ISI Essential Science Indicators. In the 2008 Research Assessment Exercise the Institute of Psychiatry was judged to have the highest research power of any UK institution within the areas of psychiatry, neuroscience and clinical psychology.
The Social, Genetic and Developmental Psychiatry (SGDP) Centre is an interdisciplinary centre established in 1994 as a collaborative enterprise between the Medical Research Council (MRC) and the Institute of Psychiatry, King’s College, London. The range of disciplines includes psychiatry, psychology, sociology, epidemiology, statistics and genetics. The MRC SGDP Centre’s mission is to undertake research on the impact and interplay between genetic, environmental and developmental factors, and their roles in the causal processes underlying the origins and course of multifactorial mental disorders; to consider the implications for clinical practice and public health policy; and to train others in the methodologies involved.
University College London, Cancer Institute, UK
University College London (UCL) is one of the world’s leading universities, founded to open up education to all on equal terms. UCL’s outstanding research and innovative teaching drive entrepreneurial solutions to the world’s major problems.
UCL ranks highly in domestic and global league tables; it is 20th in the world (and 4th in Europe) in the 2014 Academic Ranking of World Universities, joint 5th in the world (and joint 3rd in Europe) in the 2014 QS World University Rankings and 22nd in the world (and 5th in Europe) in the 2014/15 Times Higher Education World University Rankings. For the period 1999 to 2009 it was the 13th most-cited university in the world (and most-cited in Europe). There are 32 Nobel Prize winners and three Fields Medalists amongst UCL’s alumni and current and former staff. UCL alumni include the “Father of the Nation” of each of India, Kenya and Mauritius, the inventor of the telephone, and one of the co-discoverers of the structure of DNA. All five of the naturally-occurring noble gases were discovered at UCL by William Ramsay.
UCL is part of three of the 11 biomedical research centres established by the NHS in England and is a founding member of the Francis Crick Institute and UCL Partners, the world’s largest academic health science centre. UCL has hundreds of research and teaching partnerships, including a major collaboration with Yale University, the Yale UCL Collaborative. UCL is a member of numerous academic organisations including the G5, the League of European Research Universities and the Russell Group and forms part of the ‘golden triangle’ of British universities.
University of Helsinki, Department of Public Health, Faculty of Medicine, Finland
The University of Helsinki is one of the best multidisciplinary research universities in the world. Founded in 1640, the University of Helsinki wants to strengthen its position among the world’s leading multidisciplinary research universities and to actively promote the well-being of humanity and a fair society. The high-quality research carried out by the university creates new knowledge for educating diverse specialists in various fields, and for utilization in social decision-making and the business sector.
The Faculty of Medicine has a strong research tradition ranging from basic biological research to clinical applications. The Faculty ranks fifth among European universities based on the citation index for clinical medicine.
The Finnish Twin Cohort Study is a core resource of the Department of Public Health (under Faculty of Medicine). The topics of research are primarily within the area of major risk factors for diseases such as diet, physical activity, obesity and substance use and the bibliography of the Finnish Twin study represents over 600 published papers, book chapters and over 50 theses.
Classical twin studies and genome wide association studies (GWAS) have played an important role in our genetic epidemiology studies of complex traits. In addition, to capture the ‘missing heritability’ from GWAS we investigate rare genetic variants, SNPs with liberal p-values, and epigenetic marks.
As a genetic isolate, a homogenous population and comprehensive health care, Finland offers many advantages for the discovery and characterization of genetic and epigenetic influences on complex traits and diseases.
Fundacio Institut D’Investigacio Biomedica de Bellvitge, Spain
Bellvitge Biomedical Research Institute (IDIBELL) is a research centre focused on biomedicine, where the high-level basic research focuses and works on relevant clinical matters and fosters economic development.
IDIBELL is a foundation created in 2004 from the merger of several research entities. The centre manages the research of the Bellvitge University Hospital, the Institut Català d’Oncologia (Catalan Institute of Oncology) and the University of Barcelona.
The Bellvitge Biomedical Research Institute is located in the south of Barcelona. Its facilities are distributed among the Hospital Duran i Reynals, the Bellvitge University Hospital and the buildings belonging to the campus of the University of Barcelona in Bellvitge.
A key aspect of the research conducted by IDIBELL is its proximity to patients.
In 2008 a new research program within the IDIBELL devoted to basic research, the “Cancer Epigenetics and Biology Program” (PEBC) that is direct by Dr. Manel Esteller. The research program is supported by the Department of Health de la Generalitat de Catalunya, Ministerio de Sanidad y Consumo, Ministerio de Educación y Ciencia and the Catalan Institution for Research and Advanced Studies (ICREA). Current research projects developed at the PEBC include: cancer epigenetics, chromatin and stem cell biology, aging, cell cycle and transformation, imprinting and the identification of cancer genes.
TATAA Biocenter AB, Sweden
Founded in 2001 by pioneers in qPCR, TATAA Biocenter is the world’s largest provider of hands-on training in qPCR, Europe’s leading provider of nucleic acid analysis services by qPCR, and Sweden’s most comprehensive distributor of qPCR products. Our offer comprises the entire field of qPCR services, including commissioned services and research projects, hands-on training and highest quality products.
Diagenode SA, Belgium
Diagenode is a leading global provider of complete solutions for epigenetics research, biological sample preparation, and diagnostics assays based in Liège, Belgium and Denville, NJ, USA. The company actively develops and markets a comprehensive portfolio of products that offers complete solutions for epigenetics-related research. The company offers innovative Bioruptor® shearing and IP-Star® automation instruments, a complete range of chromatin immunoprecipitation (ChIP) and DNA methylation products to streamline DNA methylation, ChIP, and ChIP-seq workflows. Diagenode is well-known for offering the industry’s most validated antibodies including Premium antibodies® and Blueprint antibodies™. The company’s latest innovations include the Megaruptor shearing system for long fragment generation in sequencing and the SX-8G IP-Star® Compact Automated Sytem that represents the first complete system to automate ChIP and DNA methylation assays.